Get Spleen And Anemia PNG. The spleen is a small organ normally about the size of your fist. Learn about spleen location, spleen pain and other symptoms, and possible causes and treatments for enlarged spleen (splenomegaly).
Classically these are acutely developing regenerative anemias, in which rbc are coated with antibody (igg usually, but also igm and iga) and/or complement (c3b) and are prematurely removed from circulation by macrophages in the spleen (mostly), liver and bone marrow (extravascular hemolysis).
This is because the spleen acts as a filter that removes abnormal cells from the blood. Hemolytic anemia is always and without exception, a result of fast red blood cell destruction either because the red blood cells are malformed and frail or because the spleen cannot filter out these defective blood cells2. It is possible to live without it, but removal of the spleen has serious consequences. Classically these are acutely developing regenerative anemias, in which rbc are coated with antibody (igg usually, but also igm and iga) and/or complement (c3b) and are prematurely removed from circulation by macrophages in the spleen (mostly), liver and bone marrow (extravascular hemolysis).